Pipeline
We are working on the medical challenges developing technologies to fight cancer and infections diseases. The more promising technologies are in licensed and developed in our labs and being transformed into nano medicines.
Scaling-up
Irinotecan depot
Irinotecan is an oncologic drug that reduces cell reproduction by inhibiting the activity of topoisomerase I enzyme needed for DNA duplication. Recent formulation as pegylated liposomes enhances drug half-life when compared with previous formulations.
Topoisomerase I inhibition hinders cell duplication; affecting mainly fast growing cells such as cancerous. This drug is used (alone or in combination) for the treatment of colon, pancreas and small cells lung cancer.
Pegylated liposomes, Injectable suspensions
Onivyde, Ipsen
RESEARCH & DEVELOPMENT
Goserelin depot
Goserelin is a man-made analog of natural gonadotropin releasing hormone. This hormone takes part in the regulation of the production of sex hormones testosterone and estrogen. Goserenax Depot offers this treatment as an injectable implant; replacing the need for daily application for a 1-moth injection. This product has been approved for treatment of breast and prostate cancer (among others).
Goserelin acetate stimulates the production of the sex hormones testosterone and estrogen in a non-pulsatile (non-physiological) manner. This causes the disruption of the endogenous hormonal feedback systems, resulting in the down-regulation of testosterone and estrogen production.
Injectable implant
Zoladex Astra Zeneca
SCAILING UP
Cytarabine Liposomal
Cytarabine (Liposomal) is a sustained-release form of cytarabine. It is an anti-cancer («antineoplastic» or «cytotoxic») chemotherapy drug. This medication is classified as an «antimetabolite. Liposomal cytarabine is used to treat lymphomatous meningitis (lymphoma found in the lining of the brain and spinal cord).
Liposomal cytarabine is used to treat lymphomatous meningitis (lymphoma found in the lining of the brain and spinal cord).
Liposomes, Inject. Suspension
Depocyt®(longer-lasting liposomal formulation) Pacira Pharma
RESEARCH & DEVELOPMENT
Exenatide depot
Exenatide is approved «as adjunctive therapy to improve glycemic control in patients with type 2 diabetes mellitus who are taking metformin, a biguanide, or a combination of metformin and a sulfonylurea, but have not achieved adequate glycemic control.» It has now been approved for use with thiazolidinediones such as pioglitazone.
Exenatide depot action takes place in response to food entering the small intestine. Exenatide depot responds to presence of carbohydrate, in the form of glucose, by stimulating release of insulin, inhibiting release of glucagon and slowing down emptying of the stomach. Each of these three mechanisms can help to keep blood glucose levels lower.
Microspheres, Inject Lyoph.
Bydureon Astra Zeneca
RESEARCH & DEVELOPMENT
Nalteranaxe depot
Naltrexone is a medication that stops the activity of opioids. It is primarily used in the management of alcohol dependence and opioid dependence. Naltrexone helps patients overcome opioid addiction by blocking the effects of opioid drugs. It has little effect on opioid cravings.
Naltrexone is the first and only non-addictive, once-monthly medication that, when combined with counseling, is proven to help prevent relapse to opioid dependence, after detox. Naltrexone blocks opioid receptors in the brain while you work with the psychological aspects of counseling. While oral naltrexone has a demonstrated ability to decrease alcohol reinforcement, it also has pharmacotherapeutic limitations, such as a small treatment effect size, adverse events, and plasma level fluctuations.
Microspheres, Inject. Lyoph.
Vivitrol® Alkermes