Pipeline

We are working on the medical challenges developing technologies to fight cancer and infections diseases. The more promising technologies are in licensed and developed in our labs and being transformed into nano medicines.

Scaling-up

Irinotecan depot

Irinotecan is an oncologic drug that reduces cell reproduction by inhibiting the activity of topoisomerase I enzyme needed for DNA duplication. Recent formulation as pegylated liposomes enhances drug half-life when compared with previous formulations. 

Treatment

Topoisomerase I inhibition hinders cell duplication; affecting mainly fast growing cells such as cancerous. This drug is used (alone or in combination) for the treatment of colon, pancreas and small cells lung cancer.

Technology

Pegylated liposomes, Injectable suspensions

Reference product

Onivyde, Ipsen

RESEARCH & DEVELOPMENT

Goserelin depot

Goserelin is a man-made analog of natural gonadotropin releasing hormone. This hormone takes part in the regulation of the production of sex hormones testosterone and estrogen. Goserenax Depot offers this treatment as an injectable implant; replacing the need for daily application for a 1-moth injection. This product has been approved for treatment of breast and prostate cancer (among others).

Treatment

Goserelin acetate stimulates the production of the sex hormones testosterone and estrogen in a non-pulsatile (non-physiological) manner. This causes the disruption of the endogenous hormonal feedback systems, resulting in the down-regulation of testosterone and estrogen production.

Technology

Injectable implant

Reference product

Zoladex Astra Zeneca

SCAILING UP

Cytarabine Liposomal

Cytarabine (Liposomal) is a sustained-release form of cytarabine. It is an anti-cancer («antineoplastic» or «cytotoxic») chemotherapy drug. This medication is classified as an «antimetabolite. Liposomal cytarabine is used to treat lymphomatous meningitis (lymphoma found in the lining of the brain and spinal cord).

Treatment

Liposomal cytarabine is used to treat lymphomatous meningitis (lymphoma found in the lining of the brain and spinal cord).

Technology

Liposomes, Inject. Suspension

Original molecule

Depocyt®(longer-lasting liposomal formulation) Pacira Pharma

RESEARCH & DEVELOPMENT

Exenatide depot

Exenatide is approved «as adjunctive therapy to improve glycemic control in patients with type 2 diabetes mellitus who are taking metformin, a biguanide, or a combination of metformin and a sulfonylurea, but have not achieved adequate glycemic control.» It has now been approved for use with thiazolidinediones such as pioglitazone.

Treatment

Exenatide depot action takes place in response to food entering the small intestine. Exenatide depot responds to presence of carbohydrate, in the form of glucose, by stimulating release of insulin, inhibiting release of glucagon and slowing down emptying of the stomach. Each of these three mechanisms can help to keep blood glucose levels lower.

Technology

Microspheres, Inject Lyoph.

Original molecule

Bydureon Astra Zeneca

RESEARCH & DEVELOPMENT

Nalteranaxe depot

Naltrexone is a medication that stops the activity of opioids. It is primarily used in the management of alcohol dependence and opioid dependence. Naltrexone helps patients overcome opioid addiction by blocking the effects of opioid drugs. It has little effect on opioid cravings.

Treatment

Naltrexone is the first and only non-addictive, once-monthly medication that, when combined with counseling, is proven to help prevent relapse to opioid dependence, after detox. Naltrexone blocks opioid receptors in the brain while you work with the psychological aspects of counseling. While oral naltrexone has a demonstrated ability to decrease alcohol reinforcement, it also has pharmacotherapeutic limitations, such as a small treatment effect size, adverse events, and plasma level fluctuations.

Technology

Microspheres, Inject. Lyoph.

Original molecule

Vivitrol® Alkermes